Seminario impartido por Mattia Bramini (Universidad de Granada).
Resumen: The emerging interest toward applying nanomaterials for drug and gene delivery, biomedical imaging and diagnostic biosensors within the central nervous system (CNS) prompted neuroscientists to focus on the effects of the interaction of nanostructures in contact with neural systems. This seminar intends to give an overview of the studies I have carried out in the past recent years over the impact of nanotechnology to in vitro blood-brain barrier (BBB) model, primary neurons and astrocytes, as well as retina tissue. Mechanistic studies of polymeric nanoparticles (NPs) trafficking through a human BBB in vitro model will be presented, guiding researchers toward the development of improved drug-delivery systems to the CNS [1]. With regard to graphene-based materials for CNS biomedical applications, the molecular mechanisms of graphene nanosheet bio-interaction with primary neurons and glial cells together with the possible inflammatory responses [2-4], and the possibility of using both 2D and 3D graphene-based supports as biocompatible scaffolds for biomedical applications will be extensively discussed. The final aim is to exploit the conductive properties of graphene to modulate and control the activity of neural networks grown in strict contact with such structures (focusing on both nanomedicine and nanosafety features). Recently, we also challenged the CNS with other “nanotools” to potentially target specific neural disorders (i.e. retinitis pigmentosa and AgeRelated Macular Degeneration), ranging from small molecules [5] to few nanometre composite particles, with the goal to develop organic liquid artificial retina prostheses.
Finally, the latest innovative neuro-nanotechnology approach based on magnetic nanotools of my Athenea3i project will be shortly explained and discussed.
Referencias:
[1] Bramini et al. ACS Nano, 8 (5), 4304-12, 2014
[2] Bramini et al, ACS Nano, 10 (7), 7154-71, 2016
[3] Chiacchiaretta, Bramini et al, Nano Lett, 18 (9), 5827-5838, 2018
[4] Bramini, Chiacchiaretta et al, Small, 5 (15), e1900147, 2019
[5] DiFrancesco, Lodola, Colombo et al., Nat Nanotechnol, [Online ahead of print], 2020
- Fecha: Jueves, 27 de Febrero de 2020
- Lugar: Facultad de Ciencias. Aula B01.
- Horario: de 13:00 a 14:00 h
- Organiza: Grupo de Física de Fluidos y Biocoloides. Departamento de Física Aplicada.
- Más información:
Javier Montes Ruiz Cabello
e-mail: fjmontes@ugr.es
Departamento de Física Aplicada